While farmers and ranchers may argue that St. John's Wort (Hypericum perforatum) is little more than a noxious weed, herbalists have long recognized the benefits of this esteemed herb. As early as the 1500s, herbal practitioners used St. John's Wort to support a calm mood and relaxed state of mind. Today, St. John's Wort has become one of the most popularly consumed herb.